Monograph


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Riamet/Coartem (coartemether) has undergone extensive preclinical and clinical trials to provide evidence for efficacy and safety.

The evidence is outlined in the Product Monograph and appropriate pages from this document are reproduced on the next pages as follows:

Efficacy of coartemether

Coartemether produces fast parasite elimination of falciparum malaria infection
Coartemether produces prompt reduction in fever in Plasmodium falciparum infection
Coartemether produces fast and effective gametocyte clearance in Plasmodium falciparum infection
Coartemether produces excellent cure rates for Plasmodium falciparum infection
Coartemether is effective in Plasmodium falciparum multi-drug resistance areas
Summary of coartemether efficacy

Coartemether safety and tolerability

Cardiosafety studies with coartemether
Tolerability with coartemether in clinical trials
Drug-drug interactions

Summary of pharmacology of coartemether

Mode of action and pharmacodynamics
Pharmacokinetics of coartemether

References